In 2014, the Children’s National Medical Center completed a five-year National Institutes of Health (NIH)-funded effort to create hands-on, arts-based programs for elementary school students. This effort aimed to advance Next Generation Science Standards and increase the healthy choices of these children and their families. Our study showed that the flexibility of the in-school curriculum and after-school programs supported children’s learning and suited students’ wide range of backgrounds and abilities. The curriculum heightened children’s curiosity about science, their bodies, their own health, and what they can do to keep their families healthy. This experimental program revealed the challenges of working in Title 1 school situations, which necessitated a adaptable, nimble approach. The final program helped guide thinking about how health science can effectively intervene where health disparities remain a persistent challenge in the US.